Diphenoxylate is chemically an opioid and has a structure that
resembles meperidine (Demerol). It is available as an anti-diarrheal
and reportedly does not appreciably cross the blood-brain barrier,
although high doses exhibit codeine-like subjective effects, indicating
opiate activity and possible recreational value. Diphenoxylate is
primarily obtained from diphenoxylate and atropine preparations, which
is used to control diarrhea. This is probably due to the general action
of opiate antagonists in causing constipation and the reportedly low
potential for abuse in diphenoxylate profile. The diphenoxylate was
obtained in the form of Dhamotil, which contains 2.5 mg of
diphenoxylate hydrochloride per tablet and 0.025 mg of atropine
sulphate.
I obtained Dhamotil (also known as Lomotil) from the pharmacy I
frequent in Sibu – it supposedly has opiate like subjective effects
from what the pharmacist told me. He noticed a trend between people who
obtained dihydrocodeine, codeine, and buprenorphine (drug seeking users
of the opiate variety) had also bought Dhamotil in large quantities,
presumably for recreational purposes (it sure ain’t for helping them
shit, that’s for sure ;)). I was rather dubious about it, so I didn’t
look up diphenoxylate hydrochloride until I ran out of interesting
pharmaceutical solutions to experiment with and found this in my Box of
Interesting Pharmacuticals.
I was pleased with the initial results from looking up
diphenoxylate. It seems that atropine was added to diphenoxylate to
prevent the abuse of diphenoxylate, which can produce opiate like
effects in large doses. The atropine was added in sub-therapeutic doses
just to prevent the consumption of massive doses of diphenoxylate for
recreational purposes. It sounded interesting enough to experiment
with, so I consumed 20 x 2.5 mg tablets (2 blister packs) of
diphenoxylate for a total of 50 mg of diphenoxylate. This was consumed
on an empty stomach and several benzodiazepines (Dormicum and Rivotril)
were also taken on a recreational dose. Cannabis was also concurrently
used in this experiment.
I did notice a slight to moderate warmth consistent with opiate
antagonists after about an hour and this effect was quite prolonged,
lasting approximately 10 hours. This is what I wrote:
little bit of opiat3e warmth perceived
slightly sleepy too due to atropine or prrevious 3xdorms
little nausea tho cannabis was supposed to counter it
its okay i guess, to add a little bit of opaiat3e warnth to your nighty benzo + weed combo.
makes it feel more sedating…with the coldish but still noticable opiat3e warmth
The sloppy English is mainly due to the cannabis compounded by the
close key proximity of the notebook, but subjectively, there is
something interesting about diphenoxylate. The dosage I took (50 mg)
was several times the daily recommended dose but the atropine did not
have an impact on it. I can see the potential for diphenoxylate for a
cheap and mild codeine substitute and I am interested to try it again
at a higher dose (100 mg – 200 mg range) to get a more substantial
appreciation for diphenoxylate.
Hi, Huai Bin,
I came across your blog while i was trying to find out whether i took the right medicine cause i forgot the type of medicine i brought for myself. I am having diarhea today due to some food that i ate y’day. It is an effective prescription for diarhea. Anyway, just want to tell u that is fun to read your blog especially your blog about Ipoh & the “amazing” picture that u took.
Phyllis: Hello there. Yup, this is ideal for that – similar in structure with opiates but without the good effects. 😉
Thanks for reading! 🙂
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You were all ridiculous!!!
Yes
thank you for your post!
I believe this is 5 years after the blog entry was done, however … Did you try 100tabs?
If so, how did it go? Thank you for an entertaining piece.. As well as your other entertaining blog entries I’ve discovered along the way. With regard to this specific DIPHENOXYLATE trial, I must say… Well done. It was lacking in follow ups or any similar posts that I can locate, however… From one writer to another, keep up the experiments! A modern day Aldous Huxley is much needed in this boring world ! Hunter S Thompson and Bukowski are also writer styles, this world IS deficient in. Blame DEA, and the ongoing waste of taxpayer dinero, on the ” war on drugs” aka … War against anything mind altering and creativity inducing. Not all of us should be expected to fit the mold of a stuffy suit and same hair cut DEA agent. Those ones are always the freakiest, btw!
They usually have some strange toenail collection or fascination to humping their cars. With that being said , lighten up America!! And to you, dear author… Never stop writing! It would be a tragedy
27th Letter